Ursocol (UDCA) 150

Manufacturer: Sun Pharmaceutical ind. ltd.

Pharmaceutical name: Ursodeoxycholic Acid

Pack: 10 pills (150 mg)

Ursocol (UDCA) is classified as a secondary bile acid, which results from the metabolic processes of intestinal bacteria. The liver generates primary bile acids, which are then stored in the gallbladder. Upon entering the colon, primary bile acids can be converted into secondary bile acids by intestinal bacteria. Both primary and secondary bile acids play a vital role in the digestion of fats.

 

Ursocol (UDCA) is a naturally occurring bile acid stored in the gallbladder. It aids in cholesterol regulation by diminishing the absorption rate of cholesterol molecules in the intestine while also helping to break down micelles that contain cholesterol. Due to this characteristic, Ursocol (UDCA) is utilized in non-surgical treatments for gallstones.

 

For adults: 6-12 mg/kg daily, taken as a single dose before bedtime or in 2-3 divided doses for 3-4 months after radiological confirmation of stone disappearance. Doses can be unevenly distributed, with a larger dose recommended before bedtime to mitigate the rise in biliary cholesterol saturation that occurs in the early morning. Maximum dosage: 15 mg/kg. In cases of hepatic impairment: use cautiously in chronic liver disease (not including primary biliary cirrhosis).

 

Precautions: Individuals with a history of liver, gallbladder, pancreas, or bile duct conditions should use caution. Special consideration is required during pregnancy and breastfeeding.

 

Common side effects include diarrhea, stomach discomfort, itching, back pain, nausea, and vomiting.

 

Cholestyramine, charcoal, and antacids could decrease its effectiveness. Estrogens and clofibrate may interfere with the action of ursodeoxycholic acid by promoting cholesterol elimination in bile. Moreover, there may be a reduction in the effectiveness of dapsone, and aluminum-based antacids might lower absorption rates.